16 years of success


































    • Bae, Y.; Lee, T. G.; Park, J. C.; Hur, J. H.; Kim, Y.; Heo, K.; Kwak, J.; Suh, P.; Ryu, S. H.; Identification of a Compound That Directly Stimulates Phospholipase C Activity. Molecular Pharmacology 2003, 63, 1043-1050.
    • Straight, A. F.; Cheung, A.; Limouze, J.; Chen, I.; Westwood, N. J.; Sellers, J. R.; Mitchison, T. J.; Dissecting Temporal and Spatial Control of Cytokines with a myosin II Inhibitor. Science 2003, 299, 1743-1747.
    •  Nieland, T. J. F.; Penman, M.; Dori, L.; Krieger, M.; Kirchhausen, T.; Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. PNAS 2002, 99 (24), 15422-15427.
    • Windsor, J. B.; Thomas, C.; Hurley, L.; Roux, S.J.; Lloyd, A.M.; Automated Colorimetric Screen for Apyrase Inhibitors. BioTechniques 2002, 33, 1024-1030.
    • Chen, J. K.; Taipale, J.; Young, K. E.; Maiti, T.; Beachy, P. A.; Small molecule modulation of Smoothened activity. PNAS 2002, 99 (22), 14071-14076.
    • Kao, R. Y. T.; Jenkins, J. L.; Olson, K. A.; Key, M. E.; Fett, J. W.; Shapiro, R.; A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity. PNAS 2002, 99 (15), 10066-71.
    • Sohn, T. A.; Bansal, R.; Su, G. H.; Murphy, K. M.; Kern, S. E.; High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated. Carcinogenesis 2002, 23 (6), 949-957.
    • Cheung, A.; Dantzig, J. A.; Hollingworth, S.; Baylor, S. M.; Goldman, Y.E.; Mitchison, T. J.; Straight, A. F. A small-molecule inhibitor of skeletal muscle myosin II. Nature Cell Biology 2002, 4, 83-84.
    • Kondratov, R.V.; Komarov, P.G.; Becker, Y.; Ewenson, A.; Gudkov, A. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. PNAS 2001, 98 (24), 14078-83.
    • Peterson, R.T.; Mably, J.D.; Chen, J.; Fishman, M.C. Convergence of distinct pathways to heart patterning revealed by the small molecule concentramide and the mutation heart-and-soul. Current Biology 2001, 11, 1481-1491.
    • Torrance, C.J.; Agrawal, V.; Vogelstein, B.; Kinzler, K.W. Use of Isogenic Human Cancers Cells for High-throughput Screening and Drug Discovery. Nature Biotechnology 2001, 19, 940-945.
    • Sohn, T. A.; Su, G. H.; Ryu, B.; Yeo, C. J.; Kern, S. E.; High-Throughput Drug Screening of the DPC4 Tumor-Suppressor Pathway in Human Pancreatic Cancer Cells. Annals of Surgery 2001, 233 (5), 696-703.
    • Grozinger, C. M.; Chao, E.D.; Blackwell, H.E.; Moazed, D.; Schreiber, S.L. Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening. J. Bio. Chem. 2001, 276 (42), 38837.
    • Degterev, A.; Lugovskoy, A.; Cardone, M.; Mulley, B.; Wagner, G.; Mitchison, T.; Yuan, J. Identification of Small-Molecule Inhibitors of Interaction between the BH3 Domain and Bcl-xL. Nature Cell Biology 2001, 3, 173-82.
    • Peterson, R.; Link, B.A.; Dowling, J.E.; Schreiber, S.L. Small Molecule Developmental Screens Reveal the Logic and Timing of Vertebrate Development. PNAS 2000, 97, 12965-69.
    • Kim, T.; Kim, T.Y.; Lee, W.G.; Yim, J.; Kim; T.K.. Signaling Pathways to the Assembly of an Interferon-B Enhanceosome. J. Biol. Chem. 2000, 275, 16910-17.
    • Su, G.H.; Taylor, A.S.; Byungwoo, R.; Kern, S.E. A Novel Histone Deacetylase Inhibitor Identified by High-throughput Transcriptional Screening of a Compound Library. Cancer Res. 2000, 60, 3137-42.
    • Mayer, T. U.; Kapoor, T.M.; Haggarty, S.J.; King, R.W.; Screiber, S.L.; Mitchison, T.J. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-based Screen. Science 1999, 286, 971-74.
    • Komarov, P. G.; Komarova, E. A.; Kondratov, R. V.; Christov-Tselkov, K.; Coon, J. S.; Chernov, M. V.; Gudkov, A. V. A Chemical Inhibitor of p53 that Protects Mice from the Side Effects of Cancer Therapy. Science 1999, 285, 1733-37.
    • Markham, P.N.; Westhaus, E.; Klyachko, K.; Johnson, M.E.; Neyfakh, A.A. Multiple Novel Inhibitors of the NorA Multidrug Transporter of Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 1999, 43, 2404-08.

     

     

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